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People matching "Design and analysis of microarray and other experi"
Courses matching "Design and analysis of microarray and other experi"
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Analysis of multivariable and high dimensional data 
Multivariate analysis of data is performed with the aims to
1. understand the structure in data and summarise the data in simpler ways;
2. understand the relationship of one part of the data to another part; and
3. make decisions or draw inferences based on data.
The statistical analyses of multivariate data extend those of univariate data, and in doing so require
more advanced mathematical theory and computational techniques. The course begins with a
discussion of the three classical methods Principal Component Analysis, Canonical Correlation
Analysis and Discriminant Analysis which correspond to the aims above. We also learn about
Cluster Analysis, Factor Analysis and newer methods including Independent Component Analysis.
For most real data the underlying distribution is not known, but if the assumptions of multivariate
normality of the data hold, extra properties can be derived. Our treatment combines ideas,
theoretical properties and a strong computational component for each of the different methods we
discuss. For the computational part -- with Matlab -- we make use of real data and learn the use
of simulations in order to assess the performance of different methods in practice.
Topics covered:
1. Introduction to multivariate data, the multivariate normal distribution
2. Principal Component Analysis, theory and practice
3. Canonical Correlation Analysis, theory and practice
4. Discriminant Analysis, Fisher's LDA, linear and quadratic DA
5. Cluster Analysis: hierarchical and k-means methods
6. Factor Analysis and latent variables
7. Independent Component Analysis including an Introduction to Information Theory
The course will be based on my forthcoming monograph
Analysis of Multivariate and High-Dimensional Data - Theory and Practice, to be published by
Cambridge University Press.
More about this course...
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Complex Analysis III
When the real numbers are replaced by the complex numbers in the definition of the derivative of a function, the resulting (complex-)differentiable functions turn out to have many remarkable properties not enjoyed by their real analogues. These functions, usually known as holomorphic functions, have numerous applications in areas such as engineering, physics, differential equations and number theory, to name just a few. The focus of this course is on the study of holomorphic functions and their most important basic properties. Topics covered are: Complex numbers and functions; complex limits and differentiability; elementary examples; analytic functions; complex line integrals; Cauchy's theorem and the Cauchy integral formula; Taylor's theorem; zeros of holomorphic functions; RouchÃÂÃÂÃÂÃÂÃÂÃÂÃÂÿ's Theorem; the Open Mapping theorem and Inverse Function theorem; Schwarz' Lemma; automorphisms of the ball, the plane and the Riemann sphere; isolated singularities and their classification; Laurent series; the Residue Theorem; calculation of definite integrals and evaluation of infinite series using residues; outlines of the Jordan Curve Theorem, Montel's Theorem and the Riemann Mapping Theorem.
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Integration and Analysis III
The Riemann integral works well for continuous functions on closed bounded intervals, but it has certain deficiencies that cause problems, for example, in Fourier analysis and in the theory of differential equations. To overcome such deficiencies, a "new and improved" version of the integral was developed around the beginning of the twentieth century, and it is this theory with which this course is concerned. The underlying basis of the theory, measure theory, has important applications not just in analysis but also in the modern theory of probability.
Topics covered are: Set theory; Lebesgue outer measure; measurable sets; measurable functions. Integration of measurable functions over measurable sets. Convergence of sequences of functions and their integrals. General measure spaces and product measures. Fubini and Tonelli's theorems. Lp spaces. The Radon-Nikodym theorem. The Riesz representation theorem. Integration and Differentiation.
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Real Analysis
Modern mathematics and physics rely on our ability to be able to solve equations, if not in explicit exact forms, then at least in being able to establish the existence of solutions. To do this requires a knowledge of so-called ``analysis", which in many respects is just Calculus in very general settings. The foundations for this work are commenced in Real Analysis, a course that develops this basic material in a systematic and rigorous manner in the context of real-valued functions of a real variable. Topics covered are: Basic set theory. The real numbers, least upper bounds, completeness and its consequences. Sequences: convergence, subsequences, Cauchy sequences. Open, closed, and compact sets of real numbers. Continuous functions, uniform continuity. Differentiation, the Mean Value Theorem. Sequences and series of functions, pointwise and uniform convergence. Power series and Taylor series. Metric spaces: basic notions generalised from the setting of the real numbers. The space of continuous functions on a compact interval. The Contraction Principle. Picard's Theorem on the existence and uniqueness of solutions of ordinary differential equations.
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Statistical Analysis and Modelling 1
This is a first course in Statistics for mathematically inclined students. It will address the key principles underlying commonly used statistical methods such as confidence intervals, hypothesis tests, inference for means and proportions, and linear regression. It will develop a deeper mathematical understanding of these ideas, many of which will be familiar from studies in secondary school. The application of basic and more advanced statistical methods will be illustrated on a range of problems from areas such as medicine, science, technology, government, commerce and manufacturing. The use of the statistical package SPSS will be developed through a sequence of computer practicals. Topics covered will include: basic probability and random variables, fundamental distributions, inference for means and proportions, comparison of independent and paired samples, simple linear regression, diagnostics and model checking, multiple linear regression, simple factorial models, models with factors and continuous predictors.
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Topology and Analysis III
Solving equations is a crucial aspect of working in mathematics, physics, engineering, and many other fields. These equations might be straightforward algebraic statements, or complicated systems of differential equations, but there are some fundamental questions common to all of these settings: does a solution exist? If so, is it unique? And if we know of the existence of some specific solution, how do we determine it explicitly or as accurately as possible? This course develops the foundations required to rigorously establish the existence of solutions to various equations, thereby laying the basis for the study of solutions. Through an understanding of the foundations of analysis, we obtain insight critical in numerous areas of application, such areas ranging across physics, engineering, economics and finance. Topics covered are: sets, functions, metric spaces and normed linear spaces, compactness, connectedness, and completeness. Banach fixed point theorem and applications, uniform continuity and convergence. General topological spaces, generating topologies, topological invariants, quotient spaces. Introduction to Hilbert spaces and bounded operators on Hilbert spaces.
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Events matching "Design and analysis of microarray and other experi"
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Stability of time-periodic flows 15:10 Fri 10 Mar 06 :: G08 Mathematics Building University of Adelaide :: Prof. Andrew Bassom, School of Mathematics and
Statistics, University of Western Australia
Time-periodic shear layers occur naturally in a wide
range of applications from engineering to physiology. Transition to
turbulence in such flows is of practical interest and there have been
several papers dealing with the stability of flows composed of a
steady component plus an oscillatory part with zero mean. In such
flows a possible instability mechanism is associated with the mean
component so that the stability of the flow can be examined using some
sort of perturbation-type analysis. This strategy fails when the mean
part of the flow is small compared with the oscillatory component
which, of course, includes the case when the mean part is precisely
zero.
This difficulty with analytical studies has meant that the stability
of purely oscillatory flows has relied on various numerical
methods. Until very recently such techniques have only ever predicted
that the flow is stable, even though experiments suggest that they do
become unstable at high enough speeds. In this talk I shall expand on
this discrepancy with emphasis on the particular case of the so-called
flat Stokes layer. This flow, which is generated in a deep layer of
incompressible fluid lying above a flat plate which is oscillated in
its own plane, represents one of the few exact solutions of the
Navier-Stokes equations. We show theoretically that the flow does
become unstable to waves which propagate relative to the basic motion
although the theory predicts that this occurs much later than has been
found in experiments. Reasons for this discrepancy are examined by
reference to calculations for oscillatory flows in pipes and
channels. Finally, we propose some new experiments that might reduce
this disagreement between the theoretical predictions of instability
and practical realisations of breakdown in oscillatory flows.
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Homological algebra and applications - a historical survey 15:10 Fri 19 May 06 :: G08 Mathematics Building University of Adelaide :: Prof. Amnon Neeman
Homological algebra is a curious branch of
mathematics; it is a powerful tool which has been used in many diverse
places, without any clear understanding why it should be so useful.
We will give a list of applications, proceeding chronologically: first
to topology, then to complex analysis, then to algebraic geometry,
then to commutative algebra and finally (if we have time) to
non-commutative algebra. At the end of the talk I hope to be able to
say something about the part of homological algebra on which I have
worked, and its applications. That part is derived categories.
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A Bivariate Zero-inflated Poisson Regression Model and application to some Dental Epidemiological data 14:10 Fri 27 Oct 06 :: G08 Mathematics Building University of Adelaide :: University Prof Sudhir Paul
Data in the form of paired (pre-treatment, post-treatment) counts arise in the study of the effects of several treatments after accounting for possible covariate effects. An example of such a data set comes from a dental epidemiological study in Belo Horizonte (the Belo Horizonte caries prevention study) which evaluated various programmes for reducing caries. Also, these data may show extra pairs of zeros than can be accounted for by a simpler model, such as, a bivariate Poisson regression model. In such situations we propose to use a zero-inflated bivariate Poisson regression (ZIBPR) model for the paired (pre-treatment, posttreatment) count data. We develop EM algorithm to obtain maximum likelihood estimates of the parameters of the ZIBPR model. Further, we obtain exact Fisher information matrix of the maximum likelihood estimates of the parameters of the ZIBPR model and develop a procedure for testing treatment effects. The procedure to detect treatment effects based on the ZIBPR model is compared, in terms of size, by simulations, with an earlier procedure using a zero-inflated Poisson regression (ZIPR) model of the post-treatment count with the pre-treatment count treated as a covariate. The procedure based on the ZIBPR model holds level most effectively. A further simulation study indicates good power property of the procedure based on the ZIBPR model. We then compare our analysis, of the decayed, missing and filled teeth (DMFT) index data from the caries prevention study, based on the ZIBPR model with the analysis using a zero-inflated Poisson regression model in which the pre-treatment DMFT index is taken to be a covariate
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Identifying the source of photographic images by analysis of JPEG quantization artifacts 15:10 Fri 27 Apr 07 :: G08 Mathematics Building University of Adelaide :: Dr Matthew Sorell
Media...
In a forensic context, digital photographs are becoming more common as sources of evidence in criminal and civil matters. Questions that arise include identifying the make and model of a camera to assist in the gathering of physical evidence; matching photographs to a particular camera through the cameraâs unique characteristics; and determining the integrity of a digital image, including whether the image contains steganographic information. From a digital file perspective, there is also the question of whether metadata has been deliberately modified to mislead the investigator, and in the case of multiple images, whether a timeline can be established from the various timestamps within the file, imposed by the operating system or determined by other image characteristics. This talk is concerned specifically with techniques to identify the make, model series and particular source camera model given a digital image. We exploit particular characteristics of the cameraâs JPEG coder to demonstrate that such identification is possible, and that even when an image has subsequently been re-processed, there are often sufficient residual characteristics of the original coding to at least narrow down the possible camera models of interest.
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Finite Geometries: Classical Problems and Recent Developments 15:10 Fri 20 Jul 07 :: G04 Napier Building University of Adelaide :: Prof. Joseph A. Thas :: Ghent University, Belgium
In recent years there has been an increasing interest in finite projective spaces, and important applications to practical topics such as coding theory, cryptography and design of experiments have made the field even more attractive. In my talk some classical problems and recent developments will be discussed. First I will mention Segre's celebrated theorem and ovals and a purely combinatorial characterization of Hermitian curves in the projective plane over a finite field here, from the beginning, the considered pointset is contained in the projective plane over a finite field. Next, a recent elegant result on semiovals in PG(2,q), due to Gács, will be given. A second approach is where the object is described as an incidence structure satisfying certain properties; here the geometry is not a priori embedded in a projective space. This will be illustrated by a characterization of the classical inversive plane in the odd case. Another quite recent beautiful result in Galois geometry is the discovery of an infinite class of hemisystems of the Hermitian variety in PG(3,q^2), leading to new interesting classes of incidence structures, graphs and codes; before this result, just one example for GF(9), due to Segre, was known.
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The Linear Algebra of Internet Search Engines 15:10 Fri 5 Oct 07 :: G04 Napier Building University of Adelaide :: Dr Lesley Ward :: School of Mathematics and Statistics, University of South Australia
We often want to search the web for information on a given topic. Early web-search algorithms worked by counting up the number of times the words in a query topic appeared on each webpage. If the topic words appeared often on a given page, that page was ranked highly as a source of information on that topic.
More recent algorithms rely on Link Analysis. People make judgments about how useful a given page is for a given topic, and they express these judgments through the hyperlinks they choose to put on their own webpages. Link-analysis algorithms aim to mine the collective wisdom encoded in the resulting network of links.
I will discuss the linear algebra that forms the common underpinning of three link-analysis algorithms for web search. I will also present some work on refining one such algorithm, Kleinberg's HITS algorithm.
This is joint work with Joel Miller, Greg Rae, Fred Schaefer, Ayman Farahat, Tom LoFaro, Tracy Powell, Estelle Basor, and Kent Morrison. It originated in a Mathematics Clinic project at Harvey Mudd College.
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Add one part chaos, one part topology, and stir well... 13:10 Fri 19 Oct 07 :: Engineering North 132 :: Dr Matt Finn :: School of Mathematical Sciences
Media...
Stirring and mixing of fluids occurs everywhere, from adding milk to a cup of coffee, right through to industrial-scale chemical blending. So why stir in the first place? Is it possible to do it badly? And how can you make sure you do it effectively? I will attempt to answer these questions using a few thought experiments, some dynamical systems theory and a little topology.
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Similarity solutions for surface-tension driven flows 15:10 Fri 14 Mar 08 :: LG29 Napier Building University of Adelaide :: Prof John Lister :: Department of Applied Mathematics and Theoretical Physics, University of Cambridge, UK
The breakup of a mass of fluid into drops is a ubiquitous phenomenon in daily life, the natural environment and technology, with common examples including a dripping tap, ocean spray and ink-jet printing. It is a feature of many generic industrial processes such as spraying, emulsification, aeration, mixing and atomisation, and is an undesirable feature in coating and fibre spinning. Surface-tension driven pinch-off and the subsequent recoil are examples of finite-time singularities in which the interfacial curvature becomes infinite at the point of disconnection. As a result, the flow near the point of disconnection becomes self-similar and independent of initial and far-field conditions. Similarity solutions will be presented for the cases of inviscid and very viscous flow, along with comparison to experiments. In each case, a boundary-integral representation can be used both to examine the time-dependent behaviour and as the basis of a modified Newton scheme for direct solution of the similarity equations.
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Betti's Reciprocal Theorem for Inclusion and Contact Problems 15:10 Fri 1 Aug 08 :: G03 Napier Building University of Adelaide :: Prof. Patrick Selvadurai :: Department of Civil Engineering and Applied Mechanics, McGill University
Enrico Betti (1823-1892) is recognized in the mathematics community for his pioneering contributions to topology. An equally important contribution is his formulation of the reciprocity theorem applicable to elastic bodies that satisfy the classical equations of linear elasticity. Although James Clerk Maxwell (1831-1879) proposed a law of reciprocal displacements and rotations in 1864, the contribution of Betti is acknowledged for its underlying formal mathematical basis and generality. The purpose of this lecture is to illustrate how Betti's reciprocal theorem can be used to full advantage to develop compact analytical results for certain contact and inclusion problems in the classical theory of elasticity. Inclusion problems are encountered in number of areas in applied mechanics ranging from composite materials to geomechanics. In composite materials, the inclusion represents an inhomogeneity that is introduced to increase either the strength or the deformability characteristics of resulting material. In geomechanics, the inclusion represents a constructed material region, such as a ground anchor, that is introduced to provide load transfer from structural systems. Similarly, contact problems have applications to the modelling of the behaviour of indentors used in materials testing to the study of foundations used to distribute loads transmitted from structures. In the study of conventional problems the inclusions and the contact regions are directly loaded and this makes their analysis quite straightforward. When the interaction is induced by loads that are placed exterior to the indentor or inclusion, the direct analysis of the problem becomes inordinately complicated both in terns of formulation of the integral equations and their numerical solution. It is shown by a set of selected examples that the application of Betti's reciprocal theorem leads to the development of exact closed form solutions to what would otherwise be approximate solutions achievable only through the numerical solution of a set of coupled integral equations.
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The Role of Walls in Chaotic Mixing 15:10 Fri 22 Aug 08 :: G03 Napier Building University of Adelaide :: Dr Jean-Luc Thiffeault :: Department of Mathematics, University of Wisconsin - Madison
I will report on experiments of chaotic mixing in closed and open
vessels, in which a highly viscous fluid is stirred by a moving
rod. In these experiments we analyze quantitatively how the
concentration field of a low-diffusivity dye relaxes towards
homogeneity, and observe a slow algebraic decay, at odds with the
exponential decay predicted by most previous studies. Visual
observations reveal the dominant role of the vessel wall, which
strongly influences the concentration field in the entire domain and
causes the anomalous scaling. A simplified 1-D model supports our
experimental results. Quantitative analysis of the concentration
pattern leads to scalings for the distributions and the variance of
the concentration field consistent with experimental and numerical
results. I also discuss possible ways of avoiding the limiting role
of walls.
This is joint work with Emmanuelle Gouillart, Olivier Dauchot, and
Stephane Roux.
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Mathematical modelling of blood flow in curved arteries 15:10 Fri 12 Sep 08 :: G03 Napier Building University of Adelaide :: Dr Jennifer Siggers :: Imperial College London
Atherosclerosis, characterised by plaques, is the most common arterial
disease. Plaques tend to develop in regions of low mean wall shear
stress, and regions where the wall shear stress changes direction during
the course of the cardiac cycle. To investigate the effect of the
arterial geometry and driving pressure gradient on the wall shear stress
distribution we consider an idealised model of a curved artery with
uniform curvature. We assume that the flow is fully-developed and seek
solutions of the governing equations, finding the effect of the
parameters on the flow and wall shear stress distribution. Most
previous work assumes the curvature ratio is asymptotically small;
however, many arteries have significant curvature (e.g. the aortic arch
has curvature ratio approx 0.25), and in this work we consider in
particular the effect of finite curvature.
We present an extensive analysis of curved-pipe flow driven by a steady
and unsteady pressure gradients. Increasing the curvature causes the
shear stress on the inside of the bend to rise, indicating that the risk
of plaque development would be overestimated by considering only the
weak curvature limit.
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Oceanographic Research at the South Australian Research and Development Institute: opportunities for collaborative research 15:10 Fri 21 Nov 08 :: Napier G04 :: Associate Prof John Middleton :: South Australian Research and Development Institute
Increasing threats to S.A.'s fisheries and marine environment have underlined the increasing need for soundly based research into the ocean circulation and ecosystems (phyto/zooplankton) of the shelf and gulfs. With support of Marine Innovation SA, the Oceanography Program has within 2 years, grown to include 6 FTEs and a budget of over $4.8M. The program currently leads two major research projects, both of which involve numerical and applied mathematical modelling of oceanic flow and ecosystems as well as statistical techniques for the analysis of data. The first is the implementation of the Southern Australian Integrated Marine Observing System (SAIMOS) that is providing data to understand the dynamics of shelf boundary currents, monitor for climate change and understand the phyto/zooplankton ecosystems that under-pin SA's wild fisheries and aquaculture. SAIMOS involves the use of ship-based sampling, the deployment of underwater marine moorings, underwater gliders, HF Ocean RADAR, acoustic tracking of tagged fish and Autonomous Underwater vehicles.
The second major project involves measuring and modelling the ocean circulation and biological systems within Spencer Gulf and the impact on prawn larval dispersal and on the sustainability of existing and proposed aquaculture sites. The discussion will focus on opportunities for collaborative research with both faculty and students in this exciting growth area of S.A. science.
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Bursts and canards in a pituitary lactotroph model 15:10 Fri 6 Mar 09 :: Napier LG29 :: Dr Martin Wechselberger :: University of Sydney
Bursting oscillations in nerve cells have been the focus of a great deal of attention by mathematicians. These are typically studied by taking advantage of multiple time-scales in the system under study to perform a singular perturbation analysis. Bursting also occurs in hormone-secreting pituitary cells, but is characterized by fast bursts with small electrical impulses. Although the separation of time-scales is not as clear, singular perturbation analysis is still the key to understand the bursting mechanism. In particular, we will show that canards are responsible for the observed oscillatory behaviour.
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Geometric analysis on the noncommutative torus 13:10 Fri 20 Mar 09 :: School Board Room :: Prof Jonathan Rosenberg :: University of Maryland
Noncommutative geometry (in the sense of Alain Connes) involves
replacing a conventional space by a "space" in which the algebra of
functions is noncommutative. The simplest truly non-trivial
noncommutative manifold is the noncommutative 2-torus, whose algebra
of functions is also called the irrational rotation algebra. I will
discuss a number of recent results on geometric analysis on the
noncommutative torus, including the study of nonlinear noncommutative
elliptic PDEs (such as the noncommutative harmonic map equation) and
noncommutative complex analysis (with noncommutative elliptic
functions).
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Sloshing in tanks of liquefied natural gas (LNG) vessels 15:10 Wed 22 Apr 09 :: Napier LG29 :: Prof. Frederic Dias :: ENS, Cachan
The last scientific conversation I had with Ernie Tuck was on liquid impact. As a matter of fact, we discussed the paper by J.H. Milgram, Journal of Fluid Mechanics 37 (1969), entitled "The motion of a fluid in a cylindrical container with a free surface following vertical impact."
Liquid impact is a key issue in sloshing and in particular in sloshing in tanks of LNG vessels. Numerical simulations of sloshing have been performed by various groups, using various types of numerical methods. In terms of the numerical results, the outcome is often impressive, but the question remains of how relevant these results are when it comes to determining impact pressures. The numerical models are too simplified to reproduce the high variability of the measured pressures. In fact, for the time being, it is not possible to simulate accurately both global and local effects. Unfortunately it appears that local effects predominate over global effects when the behaviour of pressures is considered.
Having said this, it is important to point out that numerical studies can be quite useful to perform sensitivity analyses in idealized conditions such as a liquid mass falling under gravity on top of a horizontal wall and then spreading along the lateral sides. Simple analytical models inspired by numerical results on idealized problems can also be useful to predict trends.
The talk is organized as follows: After a brief introduction on the sloshing problem and on scaling laws, it will be explained to what extent numerical studies can be used to improve our understanding of impact pressures. Results on a liquid mass hitting a wall obtained by a finite-volume code with interface reconstruction as well as results obtained by a simple analytical model will be shown to reproduce the trends of experiments on sloshing.
This is joint work with L. Brosset (GazTransport & Technigaz), J.-M. Ghidaglia (ENS Cachan) and J.-P. Braeunig (INRIA).
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Wall turbulence: from the laboratory to the atmosphere 15:00 Fri 29 May 09 :: Napier LG29 :: Prof Ivan Marusic :: The University of Melbourne
The study of wall-bounded turbulent flows has received great attention over
the past few years as a result of high Reynolds number experiments conducted
in new high Reynolds number facilities such as the Princeton "superpipe",
the NDF facility in Chicago and the HRNBLWT at the University of Melbourne.
These experiments have brought into question the fundamental scaling laws of
the turbulence and mean flow quantities as well as revealed high Reynolds
number phenomena, which make extrapolation of low Reynolds number
results highly questionable.
In this talk these issues will be reviewed and new results from the HRNBLWT
and atmospheric surface layer on the salt-flats of Utah will be presented
documenting unique high Reynolds number phenomena. The implications for
skin-friction drag reduction technologies and improved near-wall models for
large-eddy simulation will be discussed.
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Strong Predictor-Corrector Euler Methods for Stochastic Differential Equations 15:10 Fri 19 Jun 09 :: LG29 :: Prof. Eckhard Platen :: University of Technology, Sydney
This paper introduces a new class of numerical
schemes for the pathwise approximation of solutions of stochastic
differential equations (SDEs). The proposed family of strong
predictor-corrector Euler methods are designed to handle scenario
simulation of solutions of SDEs. It has the potential to overcome
some of the numerical instabilities that are often experienced
when using the explicit Euler method. This is of importance, for
instance, in finance where martingale dynamics arise for solutions
of SDEs with multiplicative diffusion coefficients. Numerical
experiments demonstrate the improved asymptotic stability
properties of the proposed symmetric predictor-corrector Euler
methods.
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Statistical analysis for harmonized development of systemic organs in human fetuses 11:00 Thu 17 Sep 09 :: School Board Room :: Prof Kanta Naito :: Shimane University
The growth processes of human babies have been studied
sufficiently in scientific fields, but there have still been many issues
about the developments of human fetus which are not clarified. The aim of
this research is to investigate the developing process of systemic organs of
human fetuses based on the data set of measurements of fetus's bodies and
organs. Specifically, this talk is concerned with giving a mathematical
understanding for the harmonized developments of the organs of human
fetuses. The method to evaluate such harmonies is proposed by the use of the
maximal dilatation appeared in the theory of quasi-conformal mapping.
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The proof of the Poincare conjecture 15:10 Fri 25 Sep 09 :: Napier 102 :: Prof Terrence Tao :: UCLA
In a series of three papers from 2002-2003, Grigori Perelman gave a spectacular proof of the Poincare Conjecture (every smooth compact simply connected three-dimensional manifold is topologically isomorphic to a sphere), one of the most famous open problems in mathematics (and one of the seven Clay Millennium Prize Problems worth a million dollars each), by developing several new groundbreaking advances in Hamilton's theory of Ricci flow on manifolds. In this talk I describe in broad detail how the proof proceeds, and briefly discuss some of the key turning points in the argument.
About the speaker:
Terence Tao was born in Adelaide, Australia, in 1975. He has been a professor of mathematics at UCLA since 1999, having completed his PhD under Elias Stein at Princeton in 1996. Tao's areas of research include harmonic analysis, PDE, combinatorics, and number theory. He has received a number of awards, including the Salem Prize in 2000, the Bochner Prize in 2002, the Fields Medal and SASTRA Ramanujan Prize in 2006, and the MacArthur Fellowship and Ostrowski Prize in 2007. Terence Tao also currently holds the James and Carol Collins chair in mathematics at UCLA, and is a Fellow of the Royal Society and the Australian Academy of Sciences (Corresponding Member).
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Eigen-analysis of fluid-loaded compliant panels 15:10 Wed 9 Dec 09 :: Santos Lecture Theatre :: Prof Tony Lucey :: Curtin University of Technology
This presentation concerns the fluid-structure interaction (FSI) that occurs between a fluid flow and an arbitrarily deforming flexible boundary considered to be a flexible panel or a compliant coating that comprises the wetted surface of a marine vehicle. We develop and deploy an approach that is a hybrid of computational and theoretical techniques. The system studied is two-dimensional and linearised disturbances are assumed. Of particular novelty in the present work is the ability of our methods to extract a full set of fluid-structure eigenmodes for systems that have strong spatial inhomogeneity in the structure of the flexible wall.
We first present the approach and some results of the system in which an ideal, zero-pressure gradient, flow interacts with a flexible plate held at both its ends. We use a combination of boundary-element and finite-difference methods to express the FSI system as a single matrix equation in the interfacial variable. This is then couched in state-space form and standard methods used to extract the system eigenvalues. It is then shown how the incorporation of spatial inhomogeneity in the stiffness of the plate can be either stabilising or destabilising. We also show that adding a further restraint within the streamwise extent of a homogeneous panel can trigger an additional type of hydroelastic instability at low flow speeds. The mechanism for the fluid-to-structure energy transfer that underpins this instability can be explained in terms of the pressure-signal phase relative to that of the wall motion and the effect on this relationship of the added wall restraint.
We then show how the ideal-flow approach can be conceptually extended to include boundary-layer effects. The flow field is now modelled by the continuity equation and the linearised perturbation momentum equation written in velocity-velocity form. The near-wall flow field is spatially discretised into rectangular elements on an Eulerian grid and a variant of the discrete-vortex method is applied. The entire fluid-structure system can again be assembled as a linear system for a single set of unknowns - the flow-field vorticity and the wall displacements - that admits the extraction of eigenvalues. We then show how stability diagrams for the fully-coupled finite flow-structure system can be assembled, in doing so identifying classes of wall-based or fluid-based and spatio-temporal wave behaviour.
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Hartogs-type holomorphic extensions 13:10 Tue 15 Dec 09 :: School Board Room :: Prof Roman Dwilewicz :: Missouri University of Science and Technology
We will review holomorphic extension problems starting with the famous Hartogs extension theorem (1906), via Severi-Kneser-Fichera-Martinelli theorems, up to some recent (partial) results of Al Boggess (Texas A&M Univ.), Zbigniew Slodkowski (Univ. Illinois at Chicago), and the speaker. The holomorphic extension problems for holomorphic or Cauchy-Riemann functions are fundamental problems in complex analysis of several variables. The talk will be very elementary, with many figures, and accessible to graduate and even advanced undergraduate students.
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A solution to the Gromov-Vaserstein problem 15:10 Fri 29 Jan 10 :: Engineering North N 158 Chapman Lecture Theatre :: Prof Frank Kutzschebauch :: University of Berne, Switzerland
Any matrix in $SL_n (\mathbb C)$ can be written as a product of elementary matrices using the Gauss elimination process. If instead of the field of complex numbers, the entries in the matrix are elements of a more general ring, this becomes a delicate question. In particular, rings of complex-valued functions on a space are interesting cases. A deep result of Suslin gives an affirmative answer for the polynomial ring in $m$ variables in case the size $n$ of the matrix is at least 3. In the topological category, the problem was solved by Thurston and Vaserstein. For holomorphic functions on $\mathbb C^m$, the problem was posed by Gromov in the 1980s. We report on a complete solution to Gromov's problem. A main tool is the Oka-Grauert-Gromov h-principle in complex analysis. Our main theorem can be formulated as follows: In the absence of obvious topological obstructions, the Gauss elimination process can be performed in a way that depends holomorphically on the matrix. This is joint work with Bj\"orn Ivarsson.
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The fluid mechanics of gels used in tissue engineering 15:10 Fri 9 Apr 10 :: Santos Lecture Theatre :: Dr Edward Green :: University of Western Australia
Tissue engineering could be called 'the science of spare parts'.
Although currently in its infancy, its long-term aim is to grow
functional tissues and organs in vitro to replace those which have
become defective through age, trauma or disease. Recent experiments
have shown that mechanical interactions between cells and the materials
in which they are grown have an important influence on tissue
architecture, but in order to understand these effects, we first need to
understand the mechanics of the gels themselves.
Many biological gels (e.g. collagen) used in tissue engineering have a
fibrous microstructure which affects the way forces are transmitted
through the material, and which in turn affects cell migration and other
behaviours. I will present a simple continuum model of gel mechanics,
based on treating the gel as a transversely isotropic viscous material.
Two canonical problems are considered involving thin two-dimensional
films: extensional flow, and squeezing flow of the fluid between two
rigid plates. Neglecting inertia, gravity and surface tension, in each
regime we can exploit the thin geometry to obtain a leading-order
problem which is sufficiently tractable to allow the use of analytical
methods. I discuss how these results could be exploited practically to
determine the mechanical properties of real gels. If time permits, I
will also talk about work currently in progress which explores the
interaction between gel mechanics and cell behaviour.
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Estimation of sparse Bayesian networks using a score-based approach 15:10 Fri 30 Apr 10 :: School Board Room :: Dr Jessica Kasza :: University of Copenhagen
The estimation of Bayesian networks given high-dimensional data sets, with more variables than there are observations, has been the focus of much recent research. These structures provide a flexible framework for the representation of the conditional independence relationships of a set of variables, and can be particularly useful in the estimation of genetic regulatory networks given gene expression data.
In this talk, I will discuss some new research on learning sparse networks, that is, networks with many conditional independence restrictions, using a score-based approach. In the case of genetic regulatory networks, such sparsity reflects the view that each gene is regulated by relatively few other genes. The presented approach allows prior information about the overall sparsity of the underlying structure to be included in the analysis, as well as the incorporation of prior knowledge about the connectivity of individual nodes within the network.
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Whole genome analysis of repetitive DNA 15:10 Fri 21 May 10 :: Napier 209 :: Prof David Adelson :: University of Adelaide
The interspersed repeat content of mammalian genomes has been best characterized in human, mouse and cow. We carried out de novo identification of repeated elements in the equine genome and identified previously unknown elements present at low copy number. The equine genome contains typical eutherian mammal repeats. We analysed both interspersed and simple sequence repeats (SSR) genome-wide, finding that some repeat classes are spatially correlated with each other as well as with G+C content and gene density. Based on these
spatial correlations, we have confirmed recently-described ancestral vs clade-specific genome territories defined by repeat content. Territories enriched for ancestral repeats tended to be contiguous domains. To determine if these territories were evolutionarily conserved, we compared these results with a similar analysis of the human genome, and observed similar ancestral repeat enriched domains. These results indicate that ancestral, evolutionarily conserved mammalian genome territories can be identified on the basis of repeat content alone. Interspersed repeats of different ages appear to be analogous to geologic strata, allowing identification of ancient vs newly remodelled regions of mammalian genomes.
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Interpolation of complex data using spatio-temporal compressive sensing 13:00 Fri 28 May 10 :: Santos Lecture Theatre :: A/Prof Matthew Roughan :: School of Mathematical Sciences, University of Adelaide
Many complex datasets suffer from missing data, and interpolating these missing
elements is a key task in data analysis. Moreover, it is often the case that we
see only a linear combination of the desired measurements, not the measurements
themselves. For instance, in network management, it is easy to count the traffic
on a link, but harder to measure the end-to-end flows. Additionally, typical
interpolation algorithms treat either the spatial, or the temporal
components of data separately, but in many real datasets have strong
spatio-temporal structure that we would like to exploit in reconstructing the
missing data. In this talk I will describe a novel reconstruction algorithm that
exploits concepts from the growing area of compressive sensing to solve all of
these problems and more. The approach works so well on Internet traffic matrices
that we can obtain a reasonable reconstruction with as much as 98% of the
original data missing.
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The mathematics of theoretical inference in cognitive psychology 15:10 Fri 11 Jun 10 :: Napier LG24 :: Prof John Dunn :: University of Adelaide
The aim of psychology in general, and of cognitive psychology in particular, is to construct theoretical accounts of mental processes based on observed changes in performance on one or more cognitive tasks. The fundamental problem faced by the researcher is that these mental processes are not directly observable but must be inferred from changes in performance between different experimental conditions. This inference is further complicated by the fact that performance measures may only be monotonically related to the underlying psychological constructs. State-trace analysis provides an approach to this problem which has gained increasing interest in recent years. In this talk, I explain state-trace analysis and discuss the set of mathematical issues that flow from it. Principal among these are the challenges of statistical inference and an unexpected connection to the mathematics of oriented matroids.
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Some thoughts on wine production 15:05 Fri 18 Jun 10 :: School Board Room :: Prof Zbigniew Michalewicz :: School of Computer Science, University of Adelaide
In the modern information era, managers (e.g. winemakers) recognize the
competitive opportunities represented by decision-support tools which can
provide a significant cost savings & revenue increases for their businesses.
Wineries make daily decisions on the processing of grapes, from harvest time
(prediction of maturity of grapes, scheduling of equipment and labour, capacity
planning, scheduling of crushers) through tank farm activities (planning and
scheduling of wine and juice transfers on the tank farm) to packaging processes
(bottling and storage activities). As such operation is quite complex, the whole
area is loaded with interesting OR-related issues. These include the issues of
global vs. local optimization, relationship between prediction and optimization,
operating in dynamic environments, strategic vs. tactical optimization, and
multi-objective optimization & trade-off analysis. During the talk we address
the above issues; a few real-world applications will be shown and discussed to
emphasize some of the presented material.
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Compound and constrained regression analyses for EIV models 15:05 Fri 27 Aug 10 :: Napier LG28 :: Prof Wei Zhu :: State University of New York at Stony Brook
In linear regression analysis, randomness often exists in the independent variables and the resulting models are referred to errors-in-variables (EIV) models. The existing general EIV modeling framework, the structural model approach, is parametric and dependent on the usually unknown underlying distributions. In this work, we introduce a general non-parametric EIV modeling framework, the compound regression analysis, featuring an intuitive geometric representation and a 1-1 correspondence to the structural model. Properties, examples and further generalizations of this new modeling approach are discussed in this talk.
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Principal Component Analysis Revisited 15:10 Fri 15 Oct 10 :: Napier G04 :: Assoc. Prof Inge Koch :: University of Adelaide
Since the beginning of the 20th century, Principal Component Analysis (PCA) has been an important tool in the analysis of multivariate data. The principal components summarise data in fewer than the original number of variables without losing essential information, and thus allow a split of the data into signal and noise components. PCA is a linear method, based on elegant mathematical theory.
The increasing complexity of data together with the emergence of fast computers in the later parts of the 20th century has led to a renaissance of PCA. The growing numbers of variables (in particular, high-dimensional low sample size problems), non-Gaussian data, and functional data (where the data are curves) are posing exciting challenges to statisticians, and have resulted in new research which extends the classical theory.
I begin with the classical PCA methodology and illustrate the challenges presented by the complex data that we are now able to collect. The main part of the talk focuses on extensions of PCA: the duality of PCA and the Principal Coordinates of Multidimensional Scaling, Sparse PCA, and consistency results relating to principal components, as the dimension grows. We will also look at newer developments such as Principal Component Regression and Supervised PCA, nonlinear PCA and Functional PCA.
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Slippery issues in nano- and microscale fluid flows 11:10 Tue 30 Nov 10 :: Innova teaching suite B21 :: Dr Shaun C. Hendy :: Victoria University of Wellington
The no-slip boundary condition was considered to have been experimentally established for the flow of simple liquids over solid surfaces in the early 20th century. Nonetheless the refinement of a number of measurement techniques has recently led to the observation of nano- and microscale violations of the no-slip boundary condition by simple fluids flowing over non-wetting surfaces. However it is important to distinguish between intrinsic slip, which arises solely from the chemical interaction between the liquid and a homogeneous, atomically flat surface and effective slip, typically measured in macroscopic experiments, which emerges from the interaction of microscopic chemical heterogeneity, roughness and contaminants.
Here we consider the role of both intrinsic and effective slip boundary conditions in nanoscale and microscale fluid flows using a theoretical approach, complemented by molecular dynamics simulations, and experimental evidence where available. Firstly, we consider nanoscale flows in small capillaries, including carbon nanotubes, where we have developed and solved a generalised Lucas-Washburn equation that incorporates slip to describe the uptake of droplets. We then consider the general problem of relating effective slip to microscopic intrinsic slip and roughness, and discuss several cases where we have been able to solve this problem analytically. Finally, we look at applications of these results to carbon nanotube growth, self-cleaning surfaces, catalysis, and putting insulation in your roof.
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Bioinspired computation in combinatorial optimization: algorithms and their computational complexity 15:10 Fri 11 Mar 11 :: 7.15 Ingkarni Wardli :: Dr Frank Neumann :: The University of Adelaide
Media...
Bioinspired computation methods, such as evolutionary algorithms and ant colony
optimization, are being applied successfully to complex engineering and
combinatorial optimization problems. The computational complexity analysis of
this type of algorithms has significantly increased the theoretical
understanding of these successful algorithms. In this talk, I will give an
introduction into this field of research and present some important results
that we achieved for problems from combinatorial optimization. These results
can also be found in my recent textbook "Bioinspired Computation in
Combinatorial Optimization -- Algorithms and Their Computational Complexity".
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Classification for high-dimensional data 15:10 Fri 1 Apr 11 :: Conference Room Level 7 Ingkarni Wardli :: Associate Prof Inge Koch :: The University of Adelaide
For two-class classification problems Fisher's discriminant rule performs
well in many scenarios provided the dimension, d, is much smaller than the sample
size n. As the dimension increases, Fisher's rule may no longer be
adequate, and can perform as poorly as random guessing.
In this talk we look at new ways of overcoming this poor performance for
high-dimensional data by suitably modifying Fisher's rule, and in particular
we describe the 'Features Annealed Independence Rule (FAIR)? of Fan and Fan
(2008) and a rule based on canonical correlation analysis. I describe some
theoretical developments, and also show analysis of data which illustrate the
performance of these modified rule.
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A strong Oka principle for embeddings of some planar domains into CxC*, I 13:10 Fri 6 May 11 :: Mawson 208 :: Mr Tyson Ritter :: University of Adelaide
The Oka principle refers to a collection of results in
complex analysis which state that there are only topological
obstructions to solving certain holomorphically defined problems
involving Stein manifolds. For example, a basic version of Gromov's
Oka principle states that every continuous map from a Stein manifold
into an elliptic complex manifold is homotopic to a holomorphic map.
In these two talks I will discuss a new result showing that
if we restrict the class of source manifolds to circular domains and
fix the target as CxC* we can obtain a much stronger Oka principle:
every continuous map from a circular domain S into CxC* is homotopic
to a proper holomorphic embedding. This result has close links with
the long-standing and difficult problem of finding proper holomorphic
embeddings of Riemann surfaces into C^2, with additional motivation
from other sources.
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When statistics meets bioinformatics 12:10 Wed 11 May 11 :: Napier 210 :: Prof Patty Solomon :: School of Mathematical Sciences
Media...
Bioinformatics is a new field of research which encompasses mathematics, computer science, biology, medicine and the physical sciences. It has arisen from the need to handle and analyse the vast amounts of data being generated by the new genomics technologies. The interface of these disciplines used to be information-poor, but is now information-mega-rich, and statistics plays a central role in processing this information and making it intelligible. In this talk, I will describe a published bioinformatics study which claimed to have developed a simple test for the early detection of ovarian cancer from a blood sample. The US Food and Drug Administration was on the verge of approving the test kits for market in 2004 when demonstrated flaws in the study design and analysis led to its withdrawal. We are still waiting for an effective early biomarker test for ovarian cancer.
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A strong Oka principle for embeddings of some planar domains into CxC*, II 13:10 Fri 13 May 11 :: Mawson 208 :: Mr Tyson Ritter :: University of Adelaide
The Oka principle refers to a collection of results in
complex analysis which state that there are only topological
obstructions to solving certain holomorphically defined problems
involving Stein manifolds. For example, a basic version of Gromov's
Oka principle states that every continuous map from a Stein manifold
into an elliptic complex manifold is homotopic to a holomorphic map.
In these two talks I will discuss a new result showing that
if we restrict the class of source manifolds to circular domains and
fix the target as CxC* we can obtain a much stronger Oka principle:
every continuous map from a circular domain S into CxC* is homotopic
to a proper holomorphic embedding. This result has close links with
the long-standing and difficult problem of finding proper holomorphic
embeddings of Riemann surfaces into C^2, with additional motivation
from other sources.
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Change detection in rainfall time series for Perth, Western Australia 12:10 Mon 16 May 11 :: 5.57 Ingkarni Wardli :: Farah Mohd Isa :: University of Adelaide
There have been numerous reports that the rainfall in south Western Australia,
particularly around Perth has observed a step change decrease, which is
typically attributed to climate change. Four statistical tests are used to
assess the empirical evidence for this claim on time series from five
meteorological stations, all of which exceed 50 years. The tests used in this
study are: the CUSUM; Bayesian Change Point analysis; consecutive t-test and the
Hotellingâs T²-statistic. Results from multivariate Hotellingâs T² analysis are
compared with those from the three univariate analyses. The issue of multiple
comparisons is discussed. A summary of the empirical evidence for the claimed
step change in Perth area is given.
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Permeability of heterogeneous porous media - experiments, mathematics and computations 15:10 Fri 27 May 11 :: B.21 Ingkarni Wardli :: Prof Patrick Selvadurai :: Department of Civil Engineering and Applied Mechanics, McGill University
Permeability is a key parameter important to a variety of applications in geological engineering and in the environmental geosciences. The conventional definition of Darcy flow enables the estimation of permeability at different levels of detail. This lecture will focus on the measurement of surface permeability characteristics of a large cuboidal block of Indiana Limestone, using a surface permeameter. The paper discusses the theoretical developments, the solution of the resulting triple integral equations and associated computational treatments that enable the mapping of the near surface permeability of the cuboidal region. This data combined with a kriging procedure is used to develop results for the permeability distribution at the interior of the cuboidal region. Upon verification of the absence of dominant pathways for fluid flow through the cuboidal region, estimates are obtained for the "Effective Permeability" of the cuboid using estimates proposed by Wiener, Landau and Lifschitz, King, Matheron, Journel et al., Dagan and others. The results of these estimates are compared with the geometric mean, derived form the computational estimates.
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Quantitative proteomics: data analysis and statistical challenges 10:10 Thu 30 Jun 11 :: 7.15 Ingkarni Wardli :: Dr Peter Hoffmann :: Adelaide Proteomics Centre
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Introduction to functional data analysis with applications to proteomics data 11:10 Thu 30 Jun 11 :: 7.15 Ingkarni Wardli :: A/Prof Inge Koch :: School of Mathematical Sciences
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Object oriented data analysis 14:10 Thu 30 Jun 11 :: 7.15 Ingkarni Wardli :: Prof Steve Marron :: The University of North Carolina at Chapel Hill
Object Oriented Data Analysis is the statistical analysis of populations of complex objects. In the special case of Functional Data Analysis, these data objects are curves, where standard Euclidean approaches, such as principal components analysis, have been very successful. Recent developments in medical image analysis motivate the statistical analysis of populations of more complex data objects which are elements of mildly non-Euclidean spaces, such as Lie Groups and Symmetric Spaces, or of strongly non-Euclidean spaces, such as spaces of tree-structured data objects. These new contexts for Object Oriented Data Analysis create several potentially large new interfaces between mathematics and statistics. Even in situations where Euclidean analysis makes sense, there are statistical challenges because of the High Dimension Low Sample Size problem, which motivates a new type of asymptotics leading to non-standard mathematical statistics.
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Object oriented data analysis of tree-structured data objects 15:10 Fri 1 Jul 11 :: 7.15 Ingkarni Wardli :: Prof Steve Marron :: The University of North Carolina at Chapel Hill
The field of Object Oriented Data Analysis has made a lot of
progress on the statistical analysis of the variation in populations
of complex objects. A particularly challenging example of this type
is populations of tree-structured objects. Deep challenges arise,
which involve a marriage of ideas from statistics, geometry, and
numerical analysis, because the space of trees is strongly
non-Euclidean in nature. These challenges, together with three
completely different approaches to addressing them, are illustrated
using a real data example, where each data point is the tree of blood
arteries in one person's brain.
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Dealing with the GC-content bias in second-generation DNA sequence data 15:10 Fri 12 Aug 11 :: Horace Lamb :: Prof Terry Speed :: Walter and Eliza Hall Institute
Media...
The field of genomics is currently dealing with an explosion of data from so-called
second-generation DNA sequencing machines. This is creating many challenges and
opportunities for statisticians interested in the area.
In this talk I will outline the technology and the data flood, and move on to one particular
problem where the technology is used: copy-number analysis.
There we find a novel bias, which, if not dealt with properly, can dominate the signal of
interest. I will describe how we think about and summarize it, and go on to identify a
plausible source of this bias, leading up to a way of removing it.
Our approach makes use of the total variation metric on discrete measures, but apart from
this, is largely descriptive.
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Alignment of time course gene expression data sets using Hidden Markov Models 12:10 Mon 5 Sep 11 :: 5.57 Ingkarni Wardli :: Mr Sean Robinson :: University of Adelaide
Time course microarray experiments allow for insight into biological processes by measuring gene expression over a time period of interest. This project is concerned with time course data from a microarray experiment conducted on a particular variety of grapevine over the development of the grape berries at a number of different vineyards in South Australia. The aim of the project is to construct a methodology for combining the data from the different vineyards in order to obtain more precise estimates of the underlying behaviour of the genes over the development process. A major issue in doing so is that the rate of development of the grape berries is different at different vineyards.
Hidden Markov models (HMMs) are a well established methodology for modelling time series data in a number of domains and have been previously used for gene expression analysis. Modelling the grapevine data presents a unique modelling issue, namely the alignment of the expression profiles needed to combine the data from different vineyards. In this seminar, I will describe our problem, review HMMs, present an extension to HMMs and show some preliminary results modelling the grapevine data.
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Statistical analysis of metagenomic data from the microbial community involved in industrial bioleaching 12:10 Mon 19 Sep 11 :: 5.57 Ingkarni Wardli :: Ms Susana Soto-Rojo :: University of Adelaide
In the last two decades heap bioleaching has become established as a successful commercial option for recovering copper from low-grade secondary sulfide ores. Genetics-based approaches have recently been employed in the task of characterizing mineral processing bacteria. Data analysis is a key issue and thus the implementation of adequate mathematical and statistical tools is of fundamental importance to draw reliable conclusions. In this talk I will give a recount of two specific problems that we have been working on. The first regarding experimental design and the latter on modeling composition and activity of the microbial consortium.
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Statistical analysis of school-based student performance data 12:10 Mon 10 Oct 11 :: 5.57 Ingkarni Wardli :: Ms Jessica Tan :: University of Adelaide
Join me in the journey of being a statistician for 15 minutes of your day (if you are not already one) and experience the task of data cleaning without having to get your own hands dirty. Most of you may have sat the Basic Skills Tests when at school or know someone who currently has to do the NAPLAN (National Assessment Program - Literacy and Numeracy) tests. Tests like these assess student progress and can be used to accurately measure school performance. In trying to answer the research question: "what conclusions about student progress and school performance can be drawn from NAPLAN data or data of a similar nature, using mathematical and statistical modelling and analysis techniques?", I have uncovered some interesting results about the data in my initial data analysis which I shall explain in this talk.
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Statistical modelling for some problems in bioinformatics 11:10 Fri 14 Oct 11 :: B.17 Ingkarni Wardli :: Professor Geoff McLachlan :: The University of Queensland
Media...
In this talk we consider some statistical analyses of data arising in
bioinformatics. The problems include the detection of differential
expression in microarray gene-expression data, the clustering of
time-course gene-expression data and, lastly, the analysis of
modern-day cytometric data. Extensions are considered to the procedures
proposed for these three problems in McLachlan et al. (Bioinformatics, 2006),
Ng et al. (Bioinformatics, 2006), and Pyne et al. (PNAS, 2009), respectively.
The latter references are available at http://www.maths.uq.edu.au/~gjm/.
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On the role of mixture distributions in the modelling of heterogeneous data 15:10 Fri 14 Oct 11 :: 7.15 Ingkarni Wardli :: Prof Geoff McLachlan :: University of Queensland
Media...
We consider the role that finite mixture distributions have played in the modelling of heterogeneous data, in particular for clustering continuous data via mixtures of normal distributions. A very brief history is given starting with the seminal papers by Day and Wolfe in the sixties before the appearance of the EM algorithm. It was the publication in 1977 of the latter algorithm by Dempster, Laird, and Rubin that greatly stimulated interest in the use of finite mixture distributions to model heterogeneous data. This is because the fitting of mixture models by maximum likelihood is a classic example of a problem that is simplified considerably by the EM's conceptual unification of maximum likelihood estimation from data that can be viewed as being incomplete. In recent times there has been a proliferation of applications in which the number of experimental units n is comparatively small but the underlying dimension p is extremely large as, for example, in microarray-based genomics and other high-throughput experimental approaches. Hence there has been increasing attention given not only in bioinformatics and machine learning, but also in mainstream statistics, to the analysis of complex data in this situation where n is small relative to p. The latter part of the talk shall focus on the modelling of such high-dimensional data using mixture distributions.
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Likelihood-free Bayesian inference: modelling drug resistance in Mycobacterium tuberculosis 15:10 Fri 21 Oct 11 :: 7.15 Ingkarni Wardli :: Dr Scott Sisson :: University of New South Wales
Media...
A central pillar of Bayesian statistical inference is Monte Carlo integration, which is based on obtaining random samples from the posterior distribution. There are a number of standard ways to obtain these samples, provided that the likelihood function can be numerically evaluated. In the last 10 years, there has been a substantial push to develop methods that permit Bayesian inference in the presence of computationally intractable likelihood functions. These methods, termed ``likelihood-free'' or approximate Bayesian computation (ABC), are now being applied extensively across many disciplines.
In this talk, I'll present a brief, non-technical overview of the ideas behind likelihood-free methods. I'll motivate and illustrate these ideas through an analysis of the epidemiological fitness cost of drug resistance in Mycobacterium tuberculosis.
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Mathematical opportunities in molecular space 15:10 Fri 28 Oct 11 :: B.18 Ingkarni Wardli :: Dr Aaron Thornton :: CSIRO
The study of molecular motion, interaction and space at the nanoscale has become a powerful tool in the area of gas separation, storage and conversion for efficient energy solutions. Modeling in this field has typically involved highly iterative computational algorithms such as molecular dynamics, Monte Carlo and quantum mechanics. Mathematical formulae in the form of analytical solutions to this field offer a range of useful and insightful advantages including optimization, bifurcation analysis and standardization. Here we present a few case scenarios where mathematics has provided insight and opportunities for further investigation.
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Metric geometry in data analysis 13:10 Fri 11 Nov 11 :: B.19 Ingkarni Wardli :: Dr Facundo Memoli :: University of Adelaide
The problem of object matching under invariances can be
studied using certain tools from metric geometry. The central idea is
to regard
objects as metric spaces (or metric measure spaces). The type of
invariance that one wishes to have in the matching is encoded by the
choice of the metrics with which one endows the objects. The standard
example is matching objects in Euclidean space under rigid isometries:
in this
situation one would endow the objects with the Euclidean metric. More
general scenarios are possible in which the desired invariance cannot
be reflected by the preservation of an ambient space metric. Several
ideas due to M. Gromov are useful for approaching this problem. The
Gromov-Hausdorff distance is a natural candidate for doing this.
However, this metric leads to very hard combinatorial optimization
problems and it is difficult to relate to previously reported
practical approaches to the problem of object matching. I will discuss
different variations of these ideas, and in particular will show a
construction of an L^p version of the Gromov-Hausdorff metric, called
the Gromov-Wassestein distance, which is based on mass transportation
ideas. This new metric directly leads to quadratic optimization
problems on continuous variables with linear constraints.
As a consequence of establishing several lower bounds, it turns out
that several invariants of metric measure spaces turn out to be
quantitatively stable in the GW sense. These invariants provide
practical tools for the discrimination of shapes and connect the GW
ideas to a number of pre-existing approaches.
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Stability analysis of nonparallel unsteady flows via separation of variables 15:30 Fri 18 Nov 11 :: 7.15 Ingkarni Wardli :: Prof Georgy Burde :: Ben-Gurion University
Media...
The problem of variables separation in the linear stability
equations, which govern the disturbance behavior in viscous
incompressible fluid flows, is discussed.
Stability of some unsteady nonparallel three-dimensional flows (exact
solutions of the Navier-Stokes equations)
is studied via separation of variables using a semi-analytical, semi-numerical approach.
In this approach, a solution with separated variables is defined in a new coordinate system which is sought together with the solution form. As the result, the linear stability problems are reduced to eigenvalue problems for ordinary differential equations which can be solved numerically.
In some specific cases, the eigenvalue
problems can be solved analytically. Those unique examples of exact
(explicit) solution of the nonparallel unsteady flow stability
problems provide a very useful test for methods used in the
hydrodynamic stability theory. Exact solutions of the stability problems for some stagnation-type flows are presented.
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Collision and instability in a rotating fluid-filled torus 15:10 Mon 12 Dec 11 :: Benham Lecture Theatre :: Dr Richard Clarke :: The University of Auckland
The simple experiment discussed in this talk, first conceived by Madden and
Mullin (JFM, 1994) as part of their investigations into the non-uniqueness
of decaying turbulent flow, consists of a fluid-filled torus which is
rotated in an horizontal plane. Turbulence within the contained flow is
triggered through a rapid change in its rotation rate. The flow
instabilities which transition the flow to this turbulent state, however,
are truly fascinating in their own right, and form the subject of this
presentation. Flow features observed in both UK- and Auckland-based
experiments will be highlighted, and explained through both boundary-layer
analysis and full DNS. In concluding we argue that this flow regime, with
its compact geometry and lack of cumbersome flow entry effects, presents an
ideal regime in which to study many prototype flow behaviours, very much in
the same spirit as Taylor-Couette flow.
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Mathematical modelling of the surface adsorption for methane on carbon nanostructures 12:10 Mon 30 Apr 12 :: 5.57 Ingkarni Wardli :: Mr Olumide Adisa :: University of Adelaide
Media...
In this talk, methane (CH4) adsorption is investigated on both graphite and in the region between two aligned single-walled carbon nanotubes, which we refer to as the groove site. The LennardâJones potential function and the continuous approximation is exploited to determine surface binding energies between a single CH4 molecule and graphite and between a single CH4 and two aligned single-walled carbon nanotubes. The modelling indicates that for a CH4 molecule interacting with graphite, the binding energy of the system is minimized when the CH4 carbon is 3.83 angstroms above the surface of the graphitic carbon, while the binding energy of the CH4âgroove site system is minimized when the CH4 carbon is 5.17 angstroms away from the common axis shared by the two aligned single-walled carbon nanotubes. These results confirm the current view that for larger groove sites, CH4 molecules in grooves are likely to move towards the outer surfaces of one of the single-walled carbon nanotubes. The results presented in this talk are computationally efficient and are in good agreement with experiments and molecular dynamics simulations, and show that CH4 adsorption on graphite and groove surfaces is more favourable at lower temperatures and higher pressures.
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Are Immigrants Discriminated in the Australian Labour Market? 12:10 Mon 7 May 12 :: 5.57 Ingkarni Wardli :: Ms Wei Xian Lim :: University of Adelaide
Media...
In this talk, I will present what I did in my honours project, which was to determine if immigrants, categorised as immigrants from English speaking countries and Non-English speaking countries, are discriminated in the Australian labour market. To determine if discrimination exists, a decomposition of the wage function is applied and analysed via regression analysis. Two different methods of estimating the unknown parameters in the wage function will be discussed:
1. the Ordinary Least Square method,
2. the Quantile Regression method.
This is your rare chance of hearing me talk about non-nanomathematics related stuff!
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Change detection in rainfall times series for Perth, Western Australia 12:10 Mon 14 May 12 :: 5.57 Ingkarni Wardli :: Ms Farah Mohd Isa :: University of Adelaide
Media...
There have been numerous reports that the rainfall in south Western Australia,
particularly around Perth has observed a step change decrease, which is
typically attributed to climate change. Four statistical tests are used to
assess the empirical evidence for this claim on time series from five
meteorological stations, all of which exceed 50 years. The tests used in this
study are: the CUSUM; Bayesian Change Point analysis; consecutive t-test and the
Hotelling's T^2-statistic. Results from multivariate Hotelling's T^2 analysis are
compared with those from the three univariate analyses. The issue of multiple
comparisons is discussed. A summary of the empirical evidence for the claimed
step change in Perth area is given.
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Introduction to quantales via axiomatic analysis 13:10 Fri 15 Jun 12 :: Napier LG28 :: Dr Ittay Weiss :: University of the South Pacific
Quantales were introduced by Mulvey in 1986 in the context of non-commutative topology with the aim of providing a concrete non-commutative framework for the foundations of quantum mechanics. Since then quantales found applications in other areas as well, among others in the work of Flagg. Flagg considers certain special quantales, called value quantales, that are desigend to capture the essential properties of ([0,\infty],\le,+) that are relevant for analysis. The result is a well behaved theory of value quantale enriched metric spaces. I will introduce the notion of quantales as if they were desigend for just this purpose, review most of the known results (since there are not too many), and address a some new results, conjectures, and questions.
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Hodge numbers and cohomology of complex algebraic varieties 13:10 Fri 10 Aug 12 :: Engineering North 218 :: Prof Gus Lehrer :: University of Sydney
Let $X$ be a complex algebraic variety defined over the ring $\mathfrak{O}$ of integers in a number field $K$ and let $\Gamma$ be a group of $\mathfrak{O}$-automorphisms of $X$. I shall discuss how the counting of rational points over reductions mod $p$ of $X$, and an analysis of the Hodge structure of the cohomology of $X$, may be used to determine the cohomology as a $\Gamma$-module. This will include some joint work with Alex Dimca and with Mark Kisin, and some classical unsolved problems.
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Drawing of Viscous Threads with Temperature-dependent Viscosity 14:10 Fri 10 Aug 12 :: Engineering North N218 :: Dr Jonathan Wylie :: City University of Hong Kong
The drawing of viscous threads is important in a wide range of industrial
applications and is a primary manufacturing process in the optical fiber
and textile industries. Most of the materials used in these processes have
viscosities that vary extremely strongly with temperature.
We investigate the role played by viscous heating in the
drawing of viscous threads. Usually, the effects of viscous heating and
inertia are neglected because the parameters that characterize them are
typically very small. However, by performing a detailed theoretical
analysis we surprisingly show that even very small amounts of viscous
heating can lead to a runaway phenomena. On the other hand, inertia
prevents runaway, and the interplay between viscous heating and inertia
results in very complicated dynamics for the system.
Even more surprisingly, in the absence of viscous heating, we find that a
new type of instability can occur when a thread is heated by a radiative
heat source. By analyzing an asymptotic limit of the Navier-Stokes
equation we provide a theory that describes the nature of this instability
and explains the seemingly counterintuitive behavior.
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Air-cooled binary Rankine cycle performance with varying ambient temperature 12:10 Mon 13 Aug 12 :: B.21 Ingkarni Wardli :: Ms Josephine Varney :: University of Adelaide
Media...
Next month, I have to give a presentation in Reno, Nevada to a group of geologists, engineers and geophysicists. So, for this talk, I am going to ask you to pretend you know very little about maths (and perhaps a lot about geology) and give me some feedback on my proposed talk.
The presentation itself, is about the effect of air-cooling on geothermal power plant performance. Air-cooling is necessary for geothermal plays in dry areas, and ambient air temperature significantly aï¬ects the power output of air-cooled geothermal power plants. Hence, a method for determining the effect of ambient air temperature on geothermal power plants is presented. Using the ambient air temperature distribution from Leigh Creek, South Australia, this analysis shows that an optimally designed plant produces 6% more energy annually than a plant designed using the mean ambient temperature.
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Star Wars Vs The Lord of the Rings: A Survival Analysis 12:10 Mon 27 Aug 12 :: B.21 Ingkarni Wardli :: Mr Christopher Davies :: University of Adelaide
Media...
Ever wondered whether you are more likely to die in the Galactic Empire or Middle Earth? Well this is the postgraduate seminar for you!
I'll be attempting to answer this question using survival analysis, the statistical method of choice for investigating time to event data.
Spoiler Warning: This talk will contain references to the deaths of characters in the above movie sagas.
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Electrokinetics of concentrated suspensions of spherical particles 15:10 Fri 28 Sep 12 :: B.21 Ingkarni Wardli :: Dr Bronwyn Bradshaw-Hajek :: University of South Australia
Electrokinetic techniques are used to gather specific information about concentrated dispersions such as electronic inks, mineral processing slurries, pharmaceutical products and biological fluids (e.g. blood). But, like most experimental techniques, intermediate quantities are measured, and consequently the method relies explicitly on theoretical modelling to extract the quantities of experimental interest. A self-consistent cell-model theory of electrokinetics can be used to determine the electrical conductivity of a dense suspension of spherical colloidal particles, and thereby determine the quantities of interest (such as the particle surface potential). The numerical predictions of this model compare well with published experimental results. High frequency asymptotic analysis of the cell-model leads to some interesting conclusions.
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Turbulent flows, semtex, and rainbows 12:10 Mon 8 Oct 12 :: B.21 Ingkarni Wardli :: Ms Sophie Calabretto :: University of Adelaide
Media...
The analysis of turbulence in transient flows has applications across a broad range of fields. We use the flow of fluid in a toroidal container as a paradigm for studying the complex dynamics due to this turbulence. To explore the dynamics of our system, we exploit the numerical capabilities of semtex; a quadrilateral spectral element DNS code. Rainbows result.
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Complex analysis in low Reynolds number hydrodynamics 15:10 Fri 12 Oct 12 :: B.20 Ingkarni Wardli :: Prof Darren Crowdy :: Imperial College London
Media...
It is a well-known fact that the methods of complex analysis provide great advantage
in studying physical problems involving a harmonic field satisfying Laplace's equation.
One example is in ideal fluid mechanics (infinite Reynolds number)
where the absence of viscosity, and the
assumption of zero vorticity, mean that it is possible to introduce a so-called
complex potential -- an analytic function from which all physical quantities of
interest can be inferred.
In the opposite limit of zero Reynolds number flows which are slow and viscous
and the governing fields are not harmonic
it is much less common to employ the methods of complex analysis
even though they continue to be relevant in certain circumstances.
This talk will give an overview of a variety of problems involving slow viscous Stokes
flows where complex analysis can be usefully employed to gain theoretical
insights. A number of example problems will be considered including
the locomotion of low-Reynolds-number micro-organisms and micro-robots,
the friction properties of superhydrophobic surfaces in microfluidics and
problems of viscous sintering and the manufacture of microstructured optic fibres (MOFs).
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Optimal Experimental Design: What Is It? 12:10 Mon 15 Oct 12 :: B.21 Ingkarni Wardli :: Mr David Price :: University of Adelaide
Media...
Optimal designs are a class of experimental designs that are optimal with respect to some statistical criterion. That answers the question, right? But what do I mean by 'optimal', and which 'statistical criterion' should you use? In this talk I will answer all these questions, and provide an overly simple example to demonstrate how optimal design works. I will then give a brief explanation of how I will use this methodology, and what chickens have to do with it.
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On the chromatic number of a random hypergraph 13:10 Fri 22 Mar 13 :: Ingkarni Wardli B21 :: Dr Catherine Greenhill :: University of New South Wales
A hypergraph is a set of vertices and a set of hyperedges, where each
hyperedge is a subset of vertices. A hypergraph is r-uniform if every
hyperedge contains r vertices. A colouring of a hypergraph is an
assignment of colours to vertices such that no hyperedge is monochromatic.
When the colours are drawn from the set {1,..,k}, this defines a
k-colouring.
We consider the problem of k-colouring a random r-uniform hypergraph
with n vertices and cn edges, where k, r and c are constants and n tends
to infinity. In this setting, Achlioptas and Naor showed that for the
case of r = 2, the chromatic number of a random graph must have one of two
easily computable values as n tends to infinity.
I will describe some joint work with Martin Dyer (Leeds) and Alan Frieze
(Carnegie Mellon), in which we generalised this result to random uniform
hypergraphs. The argument uses the second moment method, and applies a
general theorem for performing Laplace summation over a lattice. So the
proof contains something for everyone, with elements from combinatorics,
analysis and algebra.
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A stability theorem for elliptic Harnack inequalities 15:10 Fri 5 Apr 13 :: B.18 Ingkarni Wardli :: Prof Richard Bass :: University of Connecticut
Media...
Harnack inequalities are an important tool in probability theory,
analysis, and partial differential equations. The classical Harnack
inequality is just the one you learned in your graduate complex analysis
class, but there have been many extensions, to different spaces, such as
manifolds, fractals, infinite graphs, and to various sorts of elliptic operators.
A landmark result was that of Moser in 1961, where he proved the Harnack
inequality for solutions to a class of partial differential equations.
I will talk about the stability of Harnack inequalities. The main result
says that if the Harnack inequality holds for an operator on a space,
then the Harnack inequality will also hold for a large class of other operators
on that same space. This provides a generalization of the result of Moser.
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Pulsatile Flow 12:10 Mon 20 May 13 :: B.19 Ingkarni Wardli :: David Wilke :: University of Adelaide
Media...
Blood flow within the human arterial system is inherently unsteady as a consequence of the pulsations of the heart. The unsteady nature of the flow gives rise to a number of important flow features which may be critical in understanding pathologies of the cardiovascular system. For example, it is believed that large oscillations in wall shear stress may enhance the effects of artherosclerosis, among other pathologies.
In this talk I will present some of the basic concepts of pulsatile flow and follow the analysis first performed by J.R. Womersley in his seminal 1955 paper.
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Multiscale modelling couples patches of wave-like simulations 12:10 Mon 27 May 13 :: B.19 Ingkarni Wardli :: Meng Cao :: University of Adelaide
Media...
A multiscale model is proposed to significantly reduce the expensive numerical simulations of complicated waves over large spatial domains. The multiscale model is built from given microscale simulations of complicated physical processes such as sea ice or turbulent shallow water. Our long term aim is to enable macroscale simulations obtained by coupling small patches of simulations together over large physical distances. This initial work explores the coupling of patch simulations of wave-like pdes. With the line of development being to water waves we discuss the dynamics of two complementary fields called the 'depth' h and 'velocity' u. A staggered grid is used for the microscale simulation of the depth h and velocity u. We introduce a macroscale staggered grid to couple the microscale patches. Linear or quadratic interpolation provides boundary conditions on the field in each patch. Linear analysis of the whole coupled multiscale system establishes that the resultant macroscale dynamics is appropriate. Numerical simulations support the linear analysis. This multiscale method should empower the feasible computation of large scale simulations of wave-like dynamics with complicated underlying physics.
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News matching "Design and analysis of microarray and other experi"
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ARC Grant successes Congratulations to Tony Roberts, Charles Pearce, Robert Elliot, Andrew Metcalfe and all their collaborators on their success in the current round of ARC grants. The projects are "Development of innovative technologies for oil production based on the advanced theory of suspension flows in porous media" (Tony Roberts et al.), "Perturbation and approximation methods for linear operators with applications to train control, water resource management and evolution of physical systems" (Charles Pearce et al.),
"Risk Measures and Management in Finance and Actuarial Science Under Regime-Switching Models" (Robert Elliott et al.) and "A new flood design methodology for a variable and changing climate" (Andrew Metcalfe et al.) Posted Mon 26 Oct 09.
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ARC Grant successes The School of Mathematical Sciences has again had outstanding success in the ARC Discovery and Linkage Projects schemes.
Congratulations to the following staff for their success in the Discovery Project scheme:
Prof Nigel Bean, Dr Josh Ross, Prof Phil Pollett, Prof Peter Taylor, New methods for improving active adaptive management in biological systems, $255,000 over 3 years;
Dr Josh Ross, New methods for integrating population structure and stochasticity into models of disease dynamics, $248,000 over three years;
A/Prof Matt Roughan, Dr Walter Willinger, Internet traffic-matrix synthesis, $290,000 over three years;
Prof Patricia Solomon, A/Prof John Moran, Statistical methods for the analysis of critical care data, with application to the Australian and New Zealand Intensive Care Database, $310,000 over 3 years;
Prof Mathai Varghese, Prof Peter Bouwknegt, Supersymmetric quantum field theory, topology and duality, $375,000 over 3 years;
Prof Peter Taylor, Prof Nigel Bean, Dr Sophie Hautphenne, Dr Mark Fackrell, Dr Malgorzata O'Reilly, Prof Guy Latouche, Advanced matrix-analytic methods with applications, $600,000 over 3 years.
Congratulations to the following staff for their success in the Linkage Project scheme:
Prof Simon Beecham, Prof Lee White, A/Prof John Boland, Prof Phil Howlett, Dr Yvonne Stokes, Mr John Wells, Paving the way: an experimental approach to the mathematical modelling and design of permeable pavements, $370,000 over 3 years;
Dr Amie Albrecht, Prof Phil Howlett, Dr Andrew Metcalfe, Dr Peter Pudney, Prof Roderick Smith, Saving energy on trains - demonstration, evaluation, integration, $540,000 over 3 years
Posted Fri 29 Oct 10.
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New Fellow of the Australian Academy of Science Professor Mathai Varghese, Professor of Pure Mathematics and ARC Professorial Fellow within the School of Mathematical Sciences, was elected to the Australian Academy of Science. Professor Varghese's citation read "for his distinguished for his work in geometric analysis involving the topology of manifolds, including the Mathai-Quillen formalism in topological field theory.". Posted Tue 30 Nov 10.
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ARC Grant Success Congratulations to the following staff who were successful in securing funding from the Australian Research Council Discovery Projects Scheme. Associate Professor Finnur Larusson awarded $270,000 for his project Flexibility and symmetry in complex geometry; Dr Thomas Leistner, awarded $303,464 for his project Holonomy groups in Lorentzian geometry, Professor Michael Murray Murray and Dr Daniel Stevenson (Glasgow), awarded $270,000 for their project Bundle gerbes: generalisations and applications; Professor Mathai Varghese, awarded $105,000 for his project Advances in index theory and Prof Anthony Roberts and Professor Ioannis Kevrekidis (Princeton) awarded $330,000 for their project Accurate modelling of large multiscale dynamical systems for engineering and scientific
simulation and analysis Posted Tue 8 Nov 11.
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Publications matching "Design and analysis of microarray and other experi"
| Publications |
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Inversion of analytically perturbed linear operators that are singular at the origin
Howlett, P; Avrachenkov, K; Pearce, Charles; Ejov, V, Journal of Mathematical Analysis and Applications 353 (68–84) 2009 |
Optimal designs for 2-color microarray experiments
Sanchez, Penny Susan; Glonek, Garique, Biostatistics 10 (561–574) 2009 |
Portfolio risk minimization and differential games
Elliott, Robert; Siu, T, Nonlinear Analysis-Theory Methods & Applications In Press (–) 2009 |
Schlicht Envelopes of Holomorphy and Foliations by Lines
Larusson, Finnur; Shafikov, R, Journal of Geometric Analysis 19 (373–389) 2009 |
A total probability approach to flood frequency analysis in tidal river reaches
Need, Steven; Lambert, Martin; Metcalfe, Andrew, World Environmental and Water Resources Congress 2008 Ahupua'a, Honolulu 12/05/08 |
Quantitative analysis ofincorrectly-configured bogon-filter detection
Arnold, Jonathan; Maennel, Olaf; Flavel, Ashley; McMahon, Jeremy; Roughan, Matthew, Australasian Telecommunication Networks and Applications Conference, Adelaide 07/12/08 |
A mixer design for the pigtail braid
Binder, Benjamin; Cox, Stephen, Fluid Dynamics Research 40 (34–44) 2008 |
A non-linear filter
Elliott, Robert; Leung, H; Deng, J, Stochastic Analysis and Applications 26 (856–862) 2008 |
Frequency analysis of rainfall and streamflow extremes accounting for seasonal and climatic partitions
Leonard, Michael; Metcalfe, Andrew; Lambert, Martin, Journal of Hydrology 348 (135–147) 2008 |
Gene profiling for determining pluripotent genes in a time course microarray experiment
Tuke, Simon; Glonek, Garique; Solomon, Patricia, Biostatistics 10 (80–93) 2008 |
Nonlinear transient heat conduction problems for a class of inhomogeneous anisotropic materials by BEM
Azis, Mohammad; Clements, David, Engineering Analysis With Boundary Elements 32 (1054–1060) 2008 |
Optimization of a shot peening process
Petit-Renaud, F; Evans, Justin; Metcalfe, Andrew; Shaw, B, Institution of Mechanical Engineers. Proceedings. Part L: Journal of Materials: Design and Applications 222 (277–289) 2008 |
Internet traffic and multiresolution analysis
Zhang, Y; Ge, Z; Diggavi, S; Mao, Z; Roughan, Matthew; Vaishampayan, V; Willinger, W; Zhang, Y, chapter in Markov Processes and Related Topics: A Festschrift for Thomas G. Kurtz (Institute of Mathematical Statistic) 215–234, 2008 |
An architecture for IEEE 802.16 MAC scheduler design
Tang, Tze; Green, D; Rumsewicz, Michael; Bean, Nigel, 007 15th IEEE International Conference on Networks, Adelaide, Australia 19/11/07 |
Aspects of Dirac operators in analysis
Eastwood, Michael; Ryan, J, Milan Journal of Mathematics 75 (91–116) 2007 |
Gene expression analysis of multiple gastrointestinal regions reveals activation of common cell regulatory pathways following cytotoxic chemotherapy
Bowen, Joanne; Gibson, Rachel; Tsykin, Anna; Stringer, Andrea Marie; Logan, Richard; Keefe, Dorothy, International Journal of Cancer 121 (1847–1856) 2007 |
Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling
Hopwood, Blair; Tsykin, Anna; Findlay, David; Fazzalari, Nicola, Arthritis Research & Therapy 9 (WWW 1–WWW 21) 2007 |
Nonclassical symmetry solutions for reaction-diffusion equations with explicity spatial dependence
Hajek, Bronwyn; Edwards, M; Broadbridge, P; Williams, G, Nonlinear Analysis-Theory Methods & Applications 67 (2541–2552) 2007 |
Optimal multilinear estimation of a random vector under constraints of casualty and limited memory
Howlett, P; Torokhti, Anatoli; Pearce, Charles, Computational Statistics & Data Analysis 52 (869–878) 2007 |
Statistics in review; Part 2: Generalised linear models, time-to-event and time-series analysis, evidence synthesis and clinical trials
Moran, John; Solomon, Patricia, Critical care and Resuscitation 9 (187–197) 2007 |
The solution of a free boundary problem related to environmental management systems
Elliott, Robert; Filinkov, Alexei, Stochastic Analysis and Applications 25 (1189–1202) 2007 |
Experimental Design and Analysis of Microarray Data
Wilson, C; Tsykin, Anna; Wilkinson, Christopher; Abbott, C, chapter in Bioinformatics (Elsevier Ltd) 1–36, 2006 |
A Markov analysis of social learning and adaptation
Wheeler, Scott; Bean, Nigel; Gaffney, Janice; Taylor, Peter, Journal of Evolutionary Economics 16 (299–319) 2006 |
Data-recursive smoother formulae for partially observed discrete-time Markov chains
Elliott, Robert; Malcolm, William, Stochastic Analysis and Applications 24 (579–597) 2006 |
Mathematical analysis of an extended mumford-shah model for image segmentation
Tao, Trevor; Crisp, David; Van Der Hoek, John, Journal of Mathematical Imaging and Vision 24 (327–340) 2006 |
Methodology in meta-analysis: a study from critical care meta-analytic practice
Moran, John; Solomon, Patricia; Warn, D, Health Services and Outcomes Research Methodology 5 (207–226) 2006 |
On the indentation of an inhomogeneous anisotropic elastic material by multiple straight rigid punches
Clements, David; Ang, W, Engineering Analysis With Boundary Elements 30 (284–291) 2006 |
Stochastic volatility model with filtering
Elliott, Robert; MIao, H, Stochastic Analysis and Applications 24 (661–683) 2006 |
The influence of urban land-use on non-motorised transport casualties
Wedagama, D; Bird, R; Metcalfe, Andrew, Accident Analysis and Prevention 38 (1049–1057) 2006 |
Three-dimensional flow due to a microcantilever oscillating near a wall: an unsteady slender-body analysis
Clarke, Richard; Jensen, O; Billingham, J; Williams, P, Proceedings of the Royal Society of London Series A-Mathematical Physical and Engineering Sciences 462 (913–933) 2006 |
Analysis of a practical control policy for water storage in two connected dams
Howlett, P; Piantadosi, J; Pearce, Charles, chapter in Continuous optimization: Current trends and modern applications (Springer) 435–450, 2005 |
Diversity sensitivity and multimodal Bayesian statistical analysis by relative entropy
Leipnik, R; Pearce, Charles, The ANZIAM Journal 47 (277–287) 2005 |
Elastic plastic analysis of shallow shells - A new approach
Mazumdar, Jagan; Ghosh, Abir; Hewitt, J; Bhattacharya, P, The ANZIAM Journal 47 (121–130) 2005 |
Hidden Markov chain filtering for a jump diffusion model
Wu, P; Elliott, Robert, Stochastic Analysis and Applications 23 (153–163) 2005 |
Hidden Markov filter estimation of the occurrence time of an event in a financial market
Elliott, Robert; Tsoi, A, Stochastic Analysis and Applications 23 (1165–1177) 2005 |
Meta-analysis of controlled trials of ventilator therapy in acute lung injury and acute respiratory distress syndrome: an alternative perspective
Moran, John; Bersten, A; Solomon, Patricia, Intensive Care Medicine 31 (227–235) 2005 |
Smoothly parameterized ech cohomology of complex manifolds
Bailey, T; Eastwood, Michael; Gindikin, S, Journal of Geometric Analysis 15 (9–23) 2005 |
Image processing of finite size rat retinal ganglion cells using multifractal and local connected fractal analysis
Jelinek, H; Cornforth, D; Roberts, Anthony John; Landini, G; Bourke, P; Iorio, A, chapter in AI 2004: Advances in Artificial Intelligence (Springer) 961–966, 2005 |
Network-wide inter-domain routing policies: Design and realization
Maennel, Olaf; Feldmann, A; Reiser, C; Volk, R; Bohm, H, Nanog34, Seatlle, WA USA 15/05/05 |
On the analysis of a case-control study with differential measurement error
Glonek, Garique, 20th International Workshop on Statistical Modelling, Sydney, Australia 10/07/05 |
Dixmier traces as singular symmetric functionals and applications to measurable operators
Lord, Steven; Sedaev, A; Sukochev, F, Journal of Functional Analysis 224 (72–106) 2005 |
Filtering, smoothing and M-ary detection with discrete time poisson observations
Elliott, Robert; Malcolm, William; Aggoun, L, Stochastic Analysis and Applications 23 (939–952) 2005 |
Finite-dimensional filtering and control for continuous-time nonlinear systems
Elliott, Robert; Aggoun, L; Benmerzouga, A, Stochastic Analysis and Applications 22 (499–505) 2005 |
Nonlinear analysis of rubber-based polymeric materials with thermal relaxation models
Melnik, R; Strunin, D; Roberts, Anthony John, Numerical Heat Transfer Part A-Applications 47 (549–569) 2005 |
Smoothly parameterized Cech cohomology of complex manifolds
Bailey, T; Eastwood, Michael; Gindikin, S, Journal of Geometric Analysis 15 (9–23) 2005 |
A deterministic discretisation-step upper bound for state estimation via Clark transformations
Malcolm, William; Elliott, Robert; Van Der Hoek, John, J.A.M.S.A. Journal of Applied Mathematics and Stochastic Analysis 2004 (371–384) 2004 |
A sufficient condition for the uniform exponential stability of time-varying systems with noise
Grammel, G; Maizurna, Isna, Nonlinear Analysis-Theory Methods & Applications 56 (951–960) 2004 |
Factorial and time course designs for cDNA microarray experiments
Glonek, Garique; Solomon, Patricia, Biostatistics 5 (89–111) 2004 |
Gerbes, Clifford Modules and the index theorem
Murray, Michael; Singer, Michael, Annals of Global Analysis and Geometry 26 (355–367) 2004 |
Modern approach of design of welded components subjected to fatigue loading
Ghosh, Abir, Journal of Structural Engineering-ASCE 130 (812–820) 2004 |
Reactions to genetically modified food crops and how perception of risks and benefits influences consumers' information gathering
Wilson, Carlene; Evans, G; Leppard, Phillip; Syrette, J, Risk Analysis 24 (1311–1321) 2004 |
A dual-reciprocity boundary element method for a class of elliptic boundary value problems for non-homogenous anisotropic media
Ang, W; Clements, David; Vahdati, N, Engineering Analysis With Boundary Elements 27 (49–55) 2003 |
Compact Khler surfaces with trivial canonical bundle
Buchdahl, Nicholas, Annals of Global Analysis and Geometry 23 (189–204) 2003 |
Complex analysis and the Funk transform
Bailey, T; Eastwood, Michael; Gover, A; Mason, L, Journal of the Korean Mathematical Society 40 (577–593) 2003 |
Exponential stability and partial averaging
Grammel, G; Maizurna, Isna, Journal of Mathematical Analysis and Applications 283 (276–286) 2003 |
Hyperbolic monopoles and holomorphic spheres
Murray, Michael; Norbury, Paul; Singer, Michael, Annals of Global Analysis and Geometry 23 (101–128) 2003 |
Method of best successive approximations for nonlinear operators
Torokhti, Anatoli; Howlett, P; Pearce, Charles, Journal of Computational Analysis and Applications 5 (299–312) 2003 |
On nonlinear operator approximation with preassigned accuracy
Howlett, P; Pearce, Charles; Torokhti, Anatoli, Journal of Computational Analysis and Applications 5 (273–297) 2003 |
Rumours, epidemics, and processes of mass action: Synthesis and analysis
Dickinson, Rowland; Pearce, Charles, Mathematical and Computer Modelling 38 (1157–1167) 2003 |
Resampling-based multiple testing for microarray data analysis (Invited discussion of paper by Ge, Dudoit and Speed)
Glonek, Garique; Solomon, Patricia, Test 12 (50–53) 2003 |
Some aspects of the design and monitoring of clinical trials
Moran, John; Solomon, Patricia, Critical care and Resuscitation 5 (137–146) 2003 |
A concavity result for network design problems
Ketabi, Saeedeh; Salzborn, Franz, Journal of Global Optimization 24 (79–88) 2002 |
An analysis of noise enhanced information transmission in an array of comparators
McDonnell, Mark; Abbott, Derek; Pearce, Charles, Microelectronics Journal 33 (1079–1089) 2002 |
Approximating spectral invariants of Harper operators on graphs
Varghese, Mathai; Yates, Stuart, Journal of Functional Analysis 188 (111–136) 2002 |
Mathematical methods for spatially cohesive reserve design
McDonnell, Mark; Possingham, Hugh; Ball, Ian; Cousins, Elizabeth, Environmental Modeling & Assessment 7 (107–114) 2002 |
Portfolio optimization, hidden Markov models, and technical analysis of P&F-charts
Elliott, Robert; Hinz, J, International Journal of Theoretical and Applied Finance 5 (385–399) 2002 |
An edge-of-the-wedge theorum for hypersurface CR functions
Eastwood, Michael; Graham, C, Journal of Geometric Analysis 11 (589–602) 2001 |
Csiszr f-divergence, Ostrowski's inequality and mutual information
Dragomir, S; Gluscevic, Vido; Pearce, Charles, Nonlinear Analysis-Theory Methods & Applications 47 (2375–2386) 2001 |
Equivariant Seiberg-Witten Floer homology
Marcolli, M; Wang, Bai-Ling, Communications in Analysis and Geometry 9 (451–639) 2001 |
On best-approximation problems for nonlinear operators
Howlett, P; Pearce, Charles; Torokhti, Anatoli, Nonlinear Functional Analysis and Applications 6 (351–368) 2001 |
On the extended reversed Meir inequality
Guljas, B; Pearce, Charles; Pecaric, Josip, Journal of Computational Analysis and Applications 3 (243–247) 2001 |
The Mx/G/1 queue with queue length dependent service times
Choi, B; Kim, Y; Shin, Y; Pearce, Charles, J.A.M.S.A. Journal of Applied Mathematics and Stochastic Analysis 14 (399–419) 2001 |
The modelling and numerical simulation of causal non-linear systems
Howlett, P; Torokhti, Anatoli; Pearce, Charles, Nonlinear Analysis-Theory Methods & Applications 47 (5559–5572) 2001 |
Best estimators of second degree for data analysis
Howlett, P; Pearce, Charles; Torokhti, Anatoli, ASMDA 2001, Compiegne, France 12/06/01 |
A continuous time kronecker's lemma and martingale convergence
Elliott, Robert, Stochastic Analysis and Applications 19 (433–437) 2001 |
Statistical analysis of medical data: New developments - Book review
Solomon, Patricia, Biometrics 57 (327–328) 2001 |
Meta-analysis, overviews and publication bias
Solomon, Patricia; Hutton, Jonathon, Statistical Methods in Medical Research 10 (245–250) 2001 |
Spectral analysis of heart sounds and vibration analysis of heart valves
Mazumdar, Jagan, EMAC 2000, RMIT University, Melbourne, Australia 10/09/00 |
A martingale analysis of hysteretic overload control
Roughan, Matthew; Pearce, Charles, Advances in Performance Analysis 3 (1–30) 2000 |
A note on higher cohomology groups of Khler quotients
Wu, Siye, Annals of Global Analysis and Geometry 18 (569–576) 2000 |
Local Constraints on Einstein-Weyl geometries: The 3-dimensional case
Eastwood, Michael; Tod, K, Annals of Global Analysis and Geometry 18 (1–27) 2000 |
Numerical design tools for thermal replication of optical-quality surfaces
Stokes, Yvonne, Computers & Fluids 29 (401–414) 2000 |
On Anastassiou's generalizations of the Ostrowski inequality and related results
Pearce, Charles; Pecaric, Josip, Journal of Computational Analysis and Applications 2 (215–276) 2000 |
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